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Phosphorylation Profile: Research have shown that SR17018 induces a unique phosphorylation pattern with the mu-opioid receptor, differing from other known agonists like morphine and buprenorphine. This phosphorylation profile is indicative Find Out of its biased signaling capabilities
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Relevance: DAMGO is utilised like a reference total agonist in reports investigating the phosphorylation profiles of MOR. When both equally DAMGO and SR-17018 induce MOR phosphorylation, they exhibit distinctive temporal dynamics, with SR-17018 inducing extended phosphorylation. [
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